For people with infections from these fungi, this drug helps to get rid of the infection. It usually starts to work within one day, but it may take 3 days for your symptoms to improve and up to 7 days for your symptoms to disappear. Fluconazole For Valley Fever In Dogs - Anti-fungal Medication The absorption of fluconazole is not affected by food. How long for fluconazole to work for skin infection . In other words, fluconazole is more common when treatment is needed in areas where topical products. I'd ask for diflucan if your doctor is open to you being able to do that. You should be able to notice a significant improvement within 24 hours, but sometimes it can take as long as 3 days for your symptoms to disappear. Most skin infections go away over time, but some of them can infect blood, lungs or other. Fluconazole is more often used for: The major fungal infection treated with diflucan is. Why won't your doctor prescribe diflucan? I am 22 years old, s...