The general instructions are as follows: Usually, toothaches can last as long as the cause of the pain is not treated. Amazoncom Advil Dual Action Coated Caplets With Acetaminophen 250 Mg Ibuprofen And 500 Mg Acetaminophen Per Dose 2 Dose Equivalent For 8 Hour Pain Relief - 2 Count X 50 Health Household Some advil products are designed to deliver faster relief, so read the product label to see how often you can take a dose. How long does it take for advil to work for toothache . Those suffering with a toothache should see a dentist as soon as possible if the following has or does occur: A mild toothache caused by some sensitivity should go away on its own within a day. Advil, motrin, aleve, or tylenol (as long as you aren’t allergic) will help with the pain. But hang on, much depends on what is there in your stomach or for that matter, what you have eaten and munched upon recently. Meanwhile, acetaminophen acts centrally and blocks the transmission. The best otc method for...